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ATPase, Na+/K+, Heart, Pig Eurofins Panlabs panel
Assay data:1 Tested
SummaryRelated BioAssays by Target
Panlabs assay PDE6
3H-cAMP and 3H-cGMP Scintillation Proximity Assay (PDE6)
3H-cAMP and 3H-cGMP Scintillation Proximity Assay (PDE1)
Assay data:1 Activity ≤ 1 µM, 1 Tested
Phospholipase PLA2-I Eurofins-Panlabs enzyme assay
Summary
Phosphodiesterase PDE6 Eurofins-Panlabs enzyme assay
Assay data:3 Tested
Phosphodiesterase PDE1 Eurofins-Panlabs enzyme assay
Assay data:2 Tested
Protein Serine/Threonine Kinase, PKA, Non-Selective Eurofins-Panlabs enzyme assay
Assay data:1 Active, 5 Tested
SummaryCompounds, Active
PLA2 Eurofins-Panlabs selectivity data (BI)
PLA2 Eurofins SafetyScreen44 (BI)
DRUGMATRIX: ATPase, Na+/K+ enzyme inhibition (substrate: ATP)
Assay data:12 Active, 3 Activity ≤ 1 µM, 871 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µM
DRUGMATRIX: Progesterone radioligand binding (ligand: [3H] R-5020)
Assay data:47 Active, 5 Activity ≤ 1 nM, 35 Activity ≤ 1 µM, 871 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
AUC(24 hrs) in female dog at 800 mg/kg, PO
AUC(24 hrs) in male dog at 800 mg/kg, PO
AUC (24 hrs) in female Beagle dog at 100 to 300 mg/kg/day, po measured by 90 day oral toxicology study
AUC (24 hrs) in male Beagle dog at 100 to 300 mg/kg/day, po measured by 90 day oral toxicology study
AUC (24 hrs) in female Beagle dog at 30 mg/kg/day, po measured by 90 day oral toxicology study
AUC (24 hrs) in male Beagle dog at 30 mg/kg/day, po measured by 90 day oral toxicology study
AUC (24 hrs) in female Beagle dog at 10 mg/kg/day, po measured by 90 day oral toxicology study
AUC (24 hrs) in male Beagle dog at 10 mg/kg/day, po measured by 90 day oral toxicology study
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